What is Tyvalzi Injection? Uses, Side Effects, Price, Precautions & Breakthrough Treatment for Ischemic Stroke

If you have seen the person you love suffer from a stroke, you already know how precious every minute is in the pursuit of an effective cure. In India, there is a newfound hope in the treatment of stroke and the process of brain recovery. This is the Tyvalzi injection. This is indeed an innovation in medicine. This medicine not only treats the symptoms of stroke; it actually helps the brain recover from the impairment. This medicine has been approved in India by the government and was created by Sun Pharmaceutical Industries Ltd. This guide will briefly tell you what Tyvalzi is, how it actually works in the brain, and what you can expect.

What is the Tyvalzi Injection? 

Tyvalzi injection is a first-in-class prescription medicine to treat acute cerebral ischemic stroke, which is characterized by a blockage in the supply of blood to the brain. Acute cerebral ischemic stroke is a medical condition for which Tyvalzi is developed to provide treatment as a prescription medicine, and it is developed by Sun Pharmaceutical Industries Ltd, which has a license from Pharmazz Inc as the sole representative of Soovateltide, a compound able to stimulate repair of the brain. The injection is given as a treatment to a patient in a hospital setting up to 24 hours after the stroke has begun, as opposed to basic treatments, which are able to stop a patient’s condition from worsening. 

Tyvalzi Injection Composition 

The core of the Tyvalzi injection design lies in:

• Active Ingredient: Sylvateltide (30mcg/vial) is the active ingredient of this medication. It is a synthetic analog and is selective for brain receptors.
• Form: It is supplied as a freeze-dried powder contained in a vial and is required to be mixed with a liquid (diluent) prior to administration.
• Reconstitution: The powder needs to be dissolved in 5 ml of 0.9% Sodium Chloride Injection IP (sterile saline), which will act as a solution for administration purposes.
• Manufacturer: It is developed and manufactured by Sun Pharmaceutical Industries Ltd. under a license agreement with Pharmazz Inc.

Tyvalzi Injection Uses 

The primary and approved Tyvalzi injection uses in India are for acute cerebral ischemic stroke treatment. The Tyvalzi injection uses for stroke treatment is deemed critical in the early phase of patient recovery.

1. Primary Use: It is used to prevent brain damage and promote recovery when given within 24 hours of the onset of stroke. It is used in conjunction with standard stroke treatments like anticoagulants.

2. How it Helps: It stimulates the brain’s neural progenitor cells. This results in:

• Neurogenesis: Formation of new brain cells.
• Angiogenesis: The process by which new blood vessels are formed.
• This dual effect is termed neurovascular remodeling. This process increases the blood supply to injured areas.

Important Note: Although the process appears promising for other diseases too, in India, this drug is only approved for use in the case of Ischemic Stroke. This drug does not cure cancer or a brain stroke caused by blood loss.

Tyvalzi Injection Dosage

The dosages of Tyvalzi are accurate and calculated for each patient in a hospital.

• Standard Dose: 0.3 micrograms per kilogram (kg) of body weight. For example, a patient with a weight of 65 kg will require a dose of approximately 19.5 mcg.

• Administration: The dose that has been calculated is administered as a slow IV bolus injection over one minute by a doctor or a nurse.

• Treatment Schedule: There are a total of nine doses, which are administered as follows:

• Three doses on Day 1, with 3 hours between each dose.
• Three doses on Day 3.
• Three doses on Day 6.

• Key Points:

• Treatment should be initiated within 24 hours of stroke symptoms.
• It is never self-administered.
• The solution should be used immediately.

Tyvalzi Injection Storage 

To maintain the potency of the medicine, proper storage of this medicine is important.

• Unopened Vials (Powder): Keep at room temperature (20 °C to 25 °C) in a cool and dry location. Keep out of light and moisture. The unopened vials should not be refrigerated or frozen.
• After Mixing: It is now ready to use the saline solution mixed with the dry powder. The mixture that is not used will be disposed of.
• General Safety: Store the medication out of the reach and out of the view of children and animals. 

Tyvalzi Injection Benefits 

Tyvalzi provides a specific benefit that has not been accessible until now in stroke therapy:

Promotes Brain Repair: It positively promotes the creation of new brain cells and enhanced blood vessel growth, moving beyond the mere management of symptoms.

Improves Recovery Outcomes: Clinical trials proved that patients who have taken Tyvalzi have an overall better chance of functional recovery in the next 90 days compared to those undergoing basic treatment. This implies the ability of individuals to perform various activities.

Neuroprotective: This component helps surviving brain cells resist further injury following the stroke by enhancing blood circulation and having anti-cell death properties.

Made in India: As a breakthrough therapy developed in India, it offers a significant treatment option in the midst of a significantly high number of stroke patients in the country. 

Tyvalzi Injection Side Effects 

Side effects may occur with most medications, and Tyvalzi is no different. Most side effects are minor and temporary.

• Common Side Effects: They may include headache, fatigue, nausea, fever, chills, and injection site reactions, such as pain and redness.
• Less Common Side Effects: Certain patients may have side effects such as dizziness, an increase or decrease in blood pressure, rash, or muscle ache.
• Serious Side Effects (Seek immediate help): Rarely, a serious allergic reaction (trouble breathing, swollen face/lips/tongue, serious skin rash) and a liver disorder (yellowing eyes/colouring of your skin, dark urine) may also occur.
• Monitoring: Since it is administered in a hospital, healthcare staff will monitor patients closely during and after the infusion. 

Tyvalzi Injection Precautions 

With full disclosure of information to your doctor, safety in using these drugs is assured.

• Medical History: You should inform your doctor about a medical history of such conditions as brain hemorrhage, uncontrollable high blood pressure, liver and kidney diseases. 
• Allergies: You need to inform your doctor about the existence of any known allergies with special attention to those related to medicines. 
• Pregnancy & Breastfeeding: The safety of Tyvalzi in pregnancy or breastfeeding has not been proven. You are to report to your doctor in case you are pregnant, intend pregnancy or breastfeeding. 
• Other Medications: You should make your doctor aware of all other medications to avoid potential interactions. 
• Driving: When dizzy people should drive carefully in a car or a machine. 

Critical Precaution: Tyvalzi is used only to treat ischemic stroke. It must first be determined that the stroke type is not hemorrhagic (caused by bleeding) through a brain scan such as a CT scan.

Frequently Asked Questions